Do I still need insulin on Mounjaro?

Work with your doctor to find out if you need to lower the insulin amount when you start Mounjaro, and continue to keep an eye on your blood sugar readings. Many people have experienced lows when they concurrently are taking insulin with Mounjaro. While the danger is practically nonexistent for true hypoglycemia to happen on Mounjaro alone, when combined with insulin, that situation changes. Studies were done on patients with insulin in the Mounjaro trials, so it is not contraindicated. As one titrates up in doses, they may find it is no longer needed.


“In patients with type 2 diabetes, tirzepatide (5, 10, and 15 mg) was superior to titrated insulin degludec, with greater reductions in HbA1c and bodyweight at week 52 and a lower risk of hypoglycaemia. Tirzepatide showed a similar safety profile to that of GLP-1 receptor agonists.”

Once-weekly tirzepatide versus once-daily insulin degludec as add-on to metformin with or without SGLT2 inhibitors in patients with type 2 diabetes (SURPASS-3): a randomised, open-label, parallel-group, phase 3 trial

The Lancet, August 2021