A weight loss trial is currently in process as of September 2022, which will answer many more questions about this topic. However, in the trial called SURPASS-4, there were more than 13k participants and the average weight loss after 52 weeks was about 25 pounds. In the SURMOUNT-1 trial, there was a total fat mass change of 33.9% for those on Mounjaro versus placebo, who only decreased by 8.2% in comparison. The SURMOUNT-1 trial with 2,539 participants showed many achieved a 22.5% loss of their total body weight. The reduction in waist circumference was five times greater in those taking Mounjaro compared to placebo.