Mounjaro and Your Menstrual Cycle & Fertility

Because Mounjaro, as an incretin mimetic, changes metabolic hormone signaling in the body, which also creates a domino effect of other hormones in the body (including sex hormones), expect potential hormonal changes once starting these injections. There are studies on PCOS and there have also been in online groups reports of changes in womens’ cycles – suddenly having reawakened cycles, skin clearing up or getting cycle-related acne, reduction of chin hair from androgenic hormone situations in flux, and increased fertility (“oops I got pregnant and I didn’t think that was possible” posts).


“Gut hormones, including GLP‐1, have been shown to impact the reproductive system and effect fertility (Moffett & Naughton, 2020). Thus, GLP‐1 receptor signalling increases menstrual frequency and chance of pregnancy in women with polycystic ovary syndrome (PCOS) (Liu et al., 2017). Additional actions have been identified in animal studies showing that GLP‐1 mimetics can restore ovarian morphology (Sun, Ji, et al., 2016) and improve development of ovarian follicles (Yang & Wang, 2016). Moreover, GLP‐1 mimetics can reduce testicular inflammation, leading to improved sperm motility and activity in diet‐induced obese mice (Zhang et al., 2015)… The actions of GLP‐1 on fertility have yet to be fully exploited in the clinic, and further research is required to develop a suitable treatment options in respect to polycystic ovary syndrome and infertility.”

Metabolic responses and benefits of glucagon‐like peptide‐1 (GLP‐1) receptor ligands

British Journal of Pharmacology