Why does stuff taste weird now on Mounjaro?

The GLP-1 and GIP hormone receptors that Mounjaro is activating exist all throughout the body. This includes bones, the brain, and even the tongue. It changes the taste of foods for some people. They have reported that foods they used to find tasty no longer hit the spot anymore. This could also be from satiety signals sent from your brain, affecting your cravings.


Research on rats in 2020 showed that Mounjaro (tirzepatide) treated rats ended up no longer  preferring sweet and high fat foods.


Key findings:


  • Chronic treatment with TZP reduced daily food intake in high-fat fed obese mice due to a reduction in meal size and frequency.


  • Acute treatment with TZP reduced sweet taste preference (glucose, sucrose and fructose) in lean mice.


  • Chronic administration of TZP reduced high-fat diet preference in obese mice and rats.


  • Chronic treatment with TZP reduced meal frequency to a greater extent than GLP-1RA in obese mice.


  • TZP reduced high-fat diet preference in obese rats, while there was no effect of GLP-1RA


“Tirzepatide (TZP), a novel dual GIP and GLP-1 receptor agonist, has demonstrated clinically meaningful weight loss in type 2 diabetes mellitus (T2DM) patients. Preclinical data indicate that TZP lowers body weight due to a reduction in caloric intake; however, associated effects on feeding behavior have not been studied. To investigate how TZP affects homeostatic feeding, we examined its effect on markers of satiation (meal size), satiety (meal frequency) and hunger (time-interval between meals) in obese mice. Chronic treatment with TZP dose-dependently lowered body weight and food intake in high-fat fed mice. This reduction in total daily caloric intake was underlined by a reduction in meal size and frequency throughout a 14-day treatment period. Indicating that TZP’s effect on total energy intake is associated with reduced hunger and increased satiety. One driver of the current obesity epidemic is the consumption of highly palatable/calorically dense foods. To determine whether the anorexigenic action of TZP is associated with reward-related feeding, we exposed lean and obese mice to two-choice diet paradigms ((low-fat (6% of kcal from fat) vs. high-fat (40% or 60% of kcal from fat) diets). Importantly, we found that while TZP decreased total calories consumed, it also altered macronutrient preference by increasing the intake of a low-fat diet and reducing intake of a high-fat diet. Furthermore, when exposed to a series of two-choice bottle tests, TZP reduced the consumption of nutritive (fructose and sucrose) and non-nutritive (sucralose) tastants, suggesting that TZP’s anorexigenic action may be linked to the taste and caloric content of food. Taken together, these data indicate that TZP’s ability to lower daily energy intake is mediated by both a reduction in homeostatic and reward-driven food intake.”

Tirzepatide, a dual GIP and GLP-1 receptor agonist, mediates its anorexigenic effect in mice due to a reduction in homeostatic and reward-related feeding.

EASD.org virtual meeting, Brain Matters, 2020