Mounjaro · Comorbidities & special topics
What the literature (and patient experience) says about Mounjaro and PCOS, NASH, kidneys, eyes, brain, gut, fertility, cholesterol, and inflammation.
12 questions in this topic
"Herein we investigated the effects of the GLP-1 receptor agonist, Exendin-4 (Ex4), on various measures of alcohol-induced reward as well as on alcohol intake and alcohol seeking behavior in rodents.…
The SURMOUNT-3 trial article, linked to elsewhere in this document, has excellent visual aids showing comparisons between 5mg, 10mg & 15mg on many health markers, including cholesterol lowering results. ![][image12]…
Mounjaro is not a treatment for eating disorders. If you have been diagnosed with an eating disorder, discuss taking this medication with your medical providers. If you believe you have…
HbA1c Change and Diabetic Retinopathy During GLP-1 Receptor Agonist Cardiovascular Outcome Trials: A Meta-analysis and Meta-regression Diabetes Care, January 2021 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7783944/
Anti-Inflammatory Effects of GLP-1-Based Therapies beyond Glucose Control Mediators Inflamm, 2016 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4823510/ "The clinical effect observed and the direct interaction between GLP-1 and the immune system raise the possibility of…
"Dual receptor agonism is both additive and complementary, Dr. Green explained. GLP-1 activity reduces food intake, improves insulin secretion, reduces glucagon secretion, and delays gastric emptying. GIP activity also reduces…
"GLP-1 RAs may act directly on the hepatocytes. Transgenic rats deficient in dipeptidyl peptidase-4 (DPP4-), the enzyme that degrades endogenous GLP-1, have a threefold higher basal active GLP-1; they not…
The SURMOUNT-3 trial article (linked elsewhere in this document!) has much information on weight loss t results and reduction in waist circumference, with great visual aids illustrating findings on this…
There's research linking PCOS to Diabetes and also GLP-1RA therapies having a positive effect on those with PCOS. See more: https://www.healthline.com/health/diabetes/are-pcos-and-diabetes-connected Lamos EM, Malek R, Davis SN. GLP-1 receptor agonists…
"Currently, there is no disease-modifying treatment available for Alzheimer's and Parkinson's disease (AD and PD) and that includes the highly controversial approval of the Aβ-targeting antibody aducanumab for the treatment…
"Recently, studies in humans and preclinical models have found associations between alterations in the gut microbiome and the metabolic/clinical features of PCOS. It is theorized that gut dysbiosis could be…
Because Mounjaro, as an incretin mimetic, changes metabolic hormone signaling in the body, which also creates a domino effect of other hormones in the body (including sex hormones), expect potential…